Reply to Watkins et al.: Whole-genome sequencing-based identification of diverse tandem duplicator phenotypes in human cancers

Watkins et al. (1) note that tandem duplications (TDs) are a feature of two distinct cancer phenotypes, distinguished based on TD span size (1 Kb–2 Mb vs. 2–10 Mb) and breast cancer 1 ( BRCA1 ) status (inactivation vs. wild-type), present at different frequencies in triple-negative breast cancer (TNBC). The authors suggest that our recent study (2) only captures the first type of TD phenotype (TDP), and that the second form of TDP may have...