HIV-1 Integrase Binds the Viral RNA Genome and Is Essential during Virion Morphogenesis
Abstract
While an essential role of HIV-1 integrase (IN) for integration of viral cDNA into human chromosome is established, studies with IN mutants and allosteric IN inhibitors (ALLINIs) have suggested that IN can also influence viral particle maturation. However, it has remained enigmatic as to how IN contributes to virion morphogenesis. Here, we demonstrate that IN directly binds the viral RNA genome in virions. These interactions have specificity, as...
Paper Details
Title
HIV-1 Integrase Binds the Viral RNA Genome and Is Essential during Virion Morphogenesis
Published Date
Aug 1, 2016
Journal
Volume
166
Issue
5
Pages
1257 - 1268.e12
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