GUCY2C-directed CAR-T cells oppose colorectal cancer metastases without autoimmunity
Abstract
Adoptive T-cell therapy (ACT) is an emerging paradigm in which T cells are genetically modified to target cancer-associated antigens and eradicate tumors. However, challenges treating epithelial cancers with ACT reflect antigen targets that are not tumor-specific, permitting immune damage to normal tissues, and preclinical testing in artificial xenogeneic models, preventing prediction of toxicities in patients. In that context, mucosa-restricted...
Paper Details
Title
GUCY2C-directed CAR-T cells oppose colorectal cancer metastases without autoimmunity
Published Date
Sep 2, 2016
Journal
Volume
5
Issue
10
Pages
e1227897 - e1227897
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