Involvement of the dynorphin/KOR system on the nociceptive, emotional and cognitive manifestations of joint pain in mice
Abstract
Joint pain is a major clinical problem mainly associated to osteoarthritis, and characterized by articular cartilage degradation resulting in a complex chronic pain state that includes nociceptive, emotional and cognitive manifestations. Memory impairment, depressive- and anxiety-like symptoms have been reported to be associated with chronic pain, leading to a decrease of life quality. In this study, we evaluated the involvement of the...
Paper Details
Title
Involvement of the dynorphin/KOR system on the nociceptive, emotional and cognitive manifestations of joint pain in mice
Published Date
Apr 1, 2017
Journal
Volume
116
Pages
315 - 327
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