Activation mechanism of endothelin ETB receptor by endothelin-1
Abstract
The vasoconstricitor peptide endothelin and its G-protein-coupled receptor (GPCR) are involved in the development of various diseases, such as pulmonary arterial hypertension, so are important therapeutic targets. In this manuscript, the authors report the X-ray crystal structures of human endothelin type B receptor in the ligand-free form and in complex with the endogenous agonist endothelin-1. The structures and mutation analysis reveal the...
Paper Details
Title
Activation mechanism of endothelin ETB receptor by endothelin-1
Published Date
Sep 1, 2016
Journal
Volume
537
Issue
7620
Pages
363 - 368
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