Thrombospondin 1 protects pancreatic β-cells from lipotoxicity via the PERK–NRF2 pathway
Abstract
The failure of β-cells has a central role in the pathogenesis of type 2 diabetes, and the identification of novel approaches to improve functional β-cell mass is essential to prevent/revert the disease. Here we show a critical novel role for thrombospondin 1 (THBS1) in β-cell survival during lipotoxic stress in rat, mouse and human models. THBS1 acts from within the endoplasmic reticulum to activate PERK and NRF2 and induce a protective...
Paper Details
Title
Thrombospondin 1 protects pancreatic β-cells from lipotoxicity via the PERK–NRF2 pathway
Published Date
Sep 2, 2016
Journal
Volume
23
Issue
12
Pages
1995 - 2006
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Notes
History