Restoring Soluble Amyloid Precursor Protein α Functions as a Potential Treatment for A lzheimer's Disease
Abstract
Soluble amyloid precursor protein α (sAPPα), a secreted proteolytic fragment of nonamyloidogenic amyloid precursor protein (APP) processing, is known for numerous neuroprotective functions. These functions include but are not limited to proliferation, neuroprotection, synaptic plasticity, memory formation, neurogenesis, and neuritogenesis in cell culture and animal models. In addition, sAPPα influences amyloid‐β (Aβ) production by direct...
Paper Details
Title
Restoring Soluble Amyloid Precursor Protein α Functions as a Potential Treatment for A lzheimer's Disease
Published Date
Aug 17, 2016
Volume
95
Issue
4
Pages
973 - 991
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