Polyphosphate delays fibrin polymerisation and alters the mechanical properties of the fibrin network
Abstract
Summary Polyphosphate (polyP) binds to fibrin(ogen) and alters fibrin structure, generating a heterogeneous network composed of ‘knots’ interspersed by large pores. Here we show platelet-derived polyP elicits similar structural changes in fibrin and examine the mechanism by which polyP alters fibrin structure. Polymerisation of fibrinogen with thrombin and CaCl2 was studied using spinning disk confocal (SDC) microscopy. PolyP delayed fibrin...
Paper Details
Title
Polyphosphate delays fibrin polymerisation and alters the mechanical properties of the fibrin network
Published Date
Jan 1, 2016
Journal
Volume
116
Issue
11
Pages
897 - 903
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