Tissue of origin dictates branched-chain amino acid metabolism in mutant Kras-driven cancers

Science56.90
Volume: 353, Issue: 6304, Pages: 1161 - 1165
Published: Sep 9, 2016
Abstract
Tumor genetics guides patient selection for many new therapies, and cell culture studies have demonstrated that specific mutations can promote metabolic phenotypes. However, whether tissue context defines cancer dependence on specific metabolic pathways is unknown. Kras activation and Trp53 deletion in the pancreas or the lung result in pancreatic ductal adenocarinoma (PDAC) or non–small cell lung carcinoma (NSCLC), respectively, but despite the...
Paper Details
Title
Tissue of origin dictates branched-chain amino acid metabolism in mutant Kras-driven cancers
Published Date
Sep 9, 2016
Journal
Volume
353
Issue
6304
Pages
1161 - 1165
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