Loss of hypothalamic corticotropin-releasing hormone markedly reduces anxiety behaviors in mice.

Volume: 22, Issue: 5, Pages: 733 - 744
Published: May 1, 2017
Abstract
A long-standing paradigm posits that hypothalamic corticotropin-releasing hormone (CRH) regulates neuroendocrine functions such as adrenal glucocorticoid release, whereas extra-hypothalamic CRH has a key role in stressor-triggered behaviors. Here we report that hypothalamus-specific Crh knockout mice (Sim1CrhKO mice, created by crossing Crhflox with Sim1Cre mice) have absent Crh mRNA and peptide mainly in the paraventricular nucleus of the...
Paper Details
Title
Loss of hypothalamic corticotropin-releasing hormone markedly reduces anxiety behaviors in mice.
Published Date
May 1, 2017
Volume
22
Issue
5
Pages
733 - 744
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