Specific Roles of XRCC4 Paralogs PAXX and XLF during V(D)J Recombination
Abstract
Paralog of XRCC4 and XLF (PAXX) is a member of the XRCC4 superfamily and plays a role in nonhomologous end-joining (NHEJ), a DNA repair pathway critical for lymphocyte antigen receptor gene assembly. Here, we find that the functions of PAXX and XLF in V(D)J recombination are masked by redundant joining activities. Thus, combined PAXX and XLF deficiency leads to an inability to join RAG-cleaved DNA ends. Additionally, we demonstrate that PAXX...
Paper Details
Title
Specific Roles of XRCC4 Paralogs PAXX and XLF during V(D)J Recombination
Published Date
Sep 1, 2016
Journal
Volume
16
Issue
11
Pages
2967 - 2979
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