A conserved quality-control pathway that mediates degradation of unassembled ribosomal proteins
Abstract
Overproduced yeast ribosomal protein (RP) Rpl26 fails to assemble into ribosomes and is degraded in the nucleus/nucleolus by a ubiquitin-proteasome system quality control pathway comprising the E2 enzymes Ubc4/Ubc5 and the ubiquitin ligase Tom1. tom1 cells show reduced ubiquitination of multiple RPs, exceptional accumulation of detergent-insoluble proteins including multiple RPs, and hypersensitivity to imbalances in production of RPs and rRNA,...
Paper Details
Title
A conserved quality-control pathway that mediates degradation of unassembled ribosomal proteins
Published Date
Aug 23, 2016
Journal
Volume
5
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