Structure of the voltage-gated calcium channel Cav1.1 at 3.6 Å resolution

The voltage-gated calcium (Cav) channels convert membrane electrical signals to intracellular Ca2+-mediated events. Among the ten subtypes of Cav channel in mammals, Cav1.1 is specified for the excitation–contraction coupling of skeletal muscles. Here we present the cryo-electron microscopy structure of the rabbit Cav1.1 complex at a nominal resolution of 3.6 A. The inner gate of the ion-conducting α1-subunit is closed and all four...