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The antibody aducanumab reduces Aβ plaques in Alzheimer's disease.

Published on Sep 1, 2016in Nature43.07
· DOI :10.1038/nature19323
Jeff Sevigny4
Estimated H-index: 4
,
Ping Chiao5
Estimated H-index: 5
+ 25 AuthorsAlfred Sandrock24
Estimated H-index: 24
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Abstract
Aducanumab, a human monoclonal antibody that selectively targets aggregated Aβ, reduces soluble and insoluble Aβ in the brain, an action accompanied by a dose-dependent slowing of clinical decline in treated patients.
  • References (40)
  • Citations (547)
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References40
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#1Heledd H. Jarosz-Griffiths (University of Manchester)H-Index: 2
#2Elizabeth Noble (University of Manchester)H-Index: 1
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#1C Ising (WashU: Washington University in St. Louis)H-Index: 1
#2M Stanley (WashU: Washington University in St. Louis)H-Index: 1
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#1Rachelle S. Doody (BCM: Baylor College of Medicine)H-Index: 58
#2Ronald G. Thomas (UCSD: University of California, San Diego)H-Index: 52
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#1Jeffrey L. Cummings (Cleveland Clinic)H-Index: 132
#2Travis Morstorf (Touro University Nevada)H-Index: 2
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#1Jerome Barakos (CPMC: California Pacific Medical Center)H-Index: 17
#2Reisa A. Sperling (Harvard University)H-Index: 87
Last.Gregory A. RipponH-Index: 4
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#1Si Zhang (UBC: University of British Columbia)H-Index: 7
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#1Ingrid S. van Maurik (VU: VU University Amsterdam)H-Index: 1
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#2Judith M. Silverman (UBC: University of British Columbia)H-Index: 11
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