Detection and Isolation of Batch-to-Batch Parametric Drift in Crystallization Using In-Batch and Post-Batch Measurements

In this work, we focus on the development of a parametric drift detection and isolation (PDDI) method for the handling of batch-to-batch parametric drifts in a batch crystallization process used to produce hen egg-white (HEW) lysozyme crystals. We consider that the batch crystallization process is controlled by an in-batch model predictive control (MPC) system and is subject to batch-to-batch parametric drifts in the solubility, growth rates,...