The Deubiquitinase OTULIN Is an Essential Negative Regulator of Inflammation and Autoimmunity
Abstract
Methionine-1 (M1)-linked ubiquitin chains regulate the activity of NF-κB, immune homeostasis, and responses to infection. The importance of negative regulators of M1-linked chains in vivo remains poorly understood. Here, we show that the M1-specific deubiquitinase OTULIN is essential for preventing TNF-associated systemic inflammation in humans and mice. A homozygous hypomorphic mutation in human OTULIN causes a potentially fatal...
Paper Details
Title
The Deubiquitinase OTULIN Is an Essential Negative Regulator of Inflammation and Autoimmunity
Published Date
Aug 1, 2016
Journal
Volume
166
Issue
5
Pages
1215 - 1230.e20
Citation AnalysisPro
You’ll need to upgrade your plan to Pro
Looking to understand the true influence of a researcher’s work across journals & affiliations?
- Scinapse’s Top 10 Citation Journals & Affiliations graph reveals the quality and authenticity of citations received by a paper.
- Discover whether citations have been inflated due to self-citations, or if citations include institutional bias.
Notes
History