Biochemical and Biophysical Characterization of Huntingtin
Published: Jan 1, 2016
Abstract
Huntington’s disease (HD) is a fatal autosomal dominant neurodegenerative disease. HD has no cure, and patients pass away 10-20 years after the onset of symptoms. The causal mutation for HD is a trinucleotide repeat expansion in exon 1 of the huntingtin gene that leads to a polyglutamine (polyQ) repeat expansion in the N-terminal region of the huntingtin protein. Interestingly, there is a threshold of 37 polyQ repeats under which little or no...
Paper Details
Title
Biochemical and Biophysical Characterization of Huntingtin
DOI
Published Date
Jan 1, 2016
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