Targeting proprotein convertases in furin-rich lung cancer cells results in decreased in vitro and in vivo growth

Volume: 56, Issue: 3, Pages: 1182 - 1188
Published: Sep 22, 2016
Abstract
Proprotein convertases (PCs) are serine proteases with an active role in the post-translational processing of numerous inactive proteins to active proteins including many substrates of paramount importance in cancer development and progression. Furin (PCSKC3), a well-studied member of this family, is overexpressed in numerous human and experimental malignancies. In the present communication, we treated two furin-overexpressing non-small cell...
Paper Details
Title
Targeting proprotein convertases in furin-rich lung cancer cells results in decreased in vitro and in vivo growth
Published Date
Sep 22, 2016
Volume
56
Issue
3
Pages
1182 - 1188
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