Efficient Production of Gene-Modified Mice using Staphylococcus aureus Cas9
Abstract
The CRISPR/Cas system is an efficient genome-editing tool to modify genes in mouse zygotes. However, only the Streptococcus pyogenes Cas9 (SpCas9) has been systematically tested for generating gene-modified mice. The protospacer adjacent motif (PAM, 5′-NGG-3′) recognized by SpCas9 limits the number of potential target sites for this system. Staphylococcus aureus Cas9 (SaCas9), with its smaller size and unique PAM (5′-NNGRRT-3′) preferences,...
Paper Details
Title
Efficient Production of Gene-Modified Mice using Staphylococcus aureus Cas9
Published Date
Sep 2, 2016
Journal
Volume
6
Issue
1
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