The clinical relevance of altered fibrinogen packaging in the presence of 17β-estradiol and progesterone

Background The effect of endogenous hormone concentrations, specifically 17β-estradiol and progesterone, on fibrin network formation has not been established. Objectives It is essential to understand natural hormone mechanisms since these hormones are still present in circulation while hormonal contraceptives, which are associated with increased risk of venous thromboembolism, are used. Methods Due to the fact that these hormones are known to...