Genetic support for the causal role of insulin in coronary heart disease

Epidemiological studies have identified several traits associated with CHD, but few of these have been shown to be causal risk factors and thus suitable targets for treatment. Our aim was to evaluate the causal role of a large set of known CHD risk factors using single-nucleotide polymorphisms (SNPs) as instrumental variables.Based on published genome-wide association studies (GWASs), we estimated the associations between the established risk...