OR46 Detecting low level clonal somatic mutation in HLA genes using next-generation sequencing in the presence of aplastic anemia

Next-generation sequencing (NGS) has assisted in the full characterization of HLA alleles, allowing in-depth studies of how these genes can play a direct role in the pathophysiology of many diseases outside of the context of transplantation. Here, we sought to determine the degree to which NGS can be used to characterize clonal somatic mutations acquired in HLA genes during the progression of aplastic anemia. Omixon’s Holotype Kit was used to...