Targeting CDK9: a promising therapeutic opportunity in prostate cancer
Abstract
Cyclin-dependent kinase 9 (CDK9) is a key transcriptional regulator and a lucrative target for cancer treatment. Targeting CDK9 can effectively confine the hyperactivity of androgen receptor and the constitutive expression of anti-apoptotic proteins; both being main causes of prostate cancer (PCa) development and progression. In castrate-resistant PCa, traditional therapies that only target androgen receptor (AR) have become obsolete due to...
Paper Details
Title
Targeting CDK9: a promising therapeutic opportunity in prostate cancer
Published Date
Dec 1, 2016
Journal
Volume
23
Issue
12
Pages
T211 - T226
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Notes
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