Low-grade inflammation as a key mediator of the pathogenesis of osteoarthritis
Abstract
Osteoarthritis (OA) has long been viewed as a degenerative disease of cartilage, but accumulating evidence indicates that inflammation has a critical role in its pathogenesis. Furthermore, we now appreciate that OA pathogenesis involves not only breakdown of cartilage, but also remodelling of the underlying bone, formation of ectopic bone, hypertrophy of the joint capsule, and inflammation of the synovial lining. That is, OA is a disorder of the...
Paper Details
Title
Low-grade inflammation as a key mediator of the pathogenesis of osteoarthritis
Published Date
Oct 1, 2016
Journal
Volume
12
Issue
10
Pages
580 - 592
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Notes
History