Low-grade inflammation as a key mediator of the pathogenesis of osteoarthritis

Published on Oct 1, 2016in Nature Reviews Rheumatology18.55
· DOI :10.1038/nrrheum.2016.136
William A. Robinson76
Estimated H-index: 76
Christin M. Lepus9
Estimated H-index: 9
(Stanford University)
+ 4 AuthorsJeremy Sokolove26
Estimated H-index: 26
Emerging evidence indicates that the inflammatory mechanisms involved in the pathophysiology of osteoarthritis (OA) differ from those in rheumatoid arthritis. This Review explores the mechanisms of chronic, low-grade inflammation in OA, discusses the evidence of their central role in its pathogenesis, and explores how they might be targeted to prevent or treat OA.
  • References (211)
  • Citations (116)
Published on Sep 1, 2016in Journal of Bone and Mineral Metabolism2.31
Lele Liao1
Estimated H-index: 1
(CSU: Central South University),
Yiyue Chen1
Estimated H-index: 1
(CSU: Central South University),
Wanchun Wang1
Estimated H-index: 1
(CSU: Central South University)
Osteoarthritis, (OA), also known as degenerative arthritis or degenerative joint disease, is the most common form of arthritis, affecting millions of people worldwide. It is a group of mechanical abnormalities involving degradation of the joints and occurs when the protective cartilage (articular cartilage) on the ends of bones such as the knees, hips and fingers abrades over time. It mainly affects the whole joint structure, including the articular cartilage, subchondral bone and synovial tissu...
Published on Jun 1, 2016in Zeitschrift Fur Rheumatologie0.90
G.G. Song9
Estimated H-index: 9
Y. H. Seo2
Estimated H-index: 2
+ 3 AuthorsY.H. Lee9
Estimated H-index: 9
Abstract This study aimed to assess the relative efficacy and tolerability of etoricoxib, celecoxib, and naproxen at recommended dosages in patients with osteoarthritis (OA). Randomized controlled trials (RCTs) examining the efficacy and tolerability of etoricoxib 30-60 mg, celecoxib 200-400 mg, and naproxen 1000 mg, based on the number of patient withdrawals among those with OA, were included in this network meta-analysis. We performed a Bayesian random-effects network meta-analysis to combine ...
Published on Feb 1, 2016in Biochimie3.36
Le Clanche S1
Estimated H-index: 1
(Paris V: Paris Descartes University),
Bonnefont-Rousselot D1
Estimated H-index: 1
(UPMC: Pierre-and-Marie-Curie University)
+ 2 AuthorsDidier Borderie28
Estimated H-index: 28
(Paris V: Paris Descartes University)
Abstract Osteoarthritis (OA) is a degenerative disorder of the joint, principally occurring during aging, and characterized by a focal degradation of cartilage. It is the most prevalent rheumatic disease in industrialized countries and represents the second cause of disability in France. However, the etiology of OA remains unclear. There is only one cell type found in cartilage, chondrocyte, which is responsible for its repair and the synthesis of the elements of the extra-cellular matrix. A dys...
Published on Jan 14, 2016in Zeitschrift Fur Rheumatologie0.90
Gwan Gyu Song35
Estimated H-index: 35
(KU: Korea University),
Young Ho Seo12
Estimated H-index: 12
(KU: Korea University)
+ 3 AuthorsYoung Ho Lee37
Estimated H-index: 37
(KU: Korea University)
Aims This study aimed to assess the relative efficacy and tolerability of etoricoxib, celecoxib, and naproxen at recommended dosages in patients with osteoarthritis (OA).
Published on Jan 4, 2016in Journal of Clinical Investigation12.28
Michal Dudek4
Estimated H-index: 4
Nicole Gossan7
Estimated H-index: 7
+ 11 AuthorsMaya Boudiffa5
Estimated H-index: 5
Osteoarthritis (OA) is the most prevalent and debilitating joint disease, and there are currently no effective disease-modifying treatments available. Multiple risk factors for OA, such as aging, result in progressive damage and loss of articular cartilage. Autonomous circadian clocks have been identified in mouse cartilage, and environmental disruption of circadian rhythms in mice predisposes animals to OA-like damage. However, the contribution of the cartilage clock mechanisms to the maintenan...
Published on Jan 1, 2016in Annals of the Rheumatic Diseases14.30
R.F. Schelbergen11
Estimated H-index: 11
(Radboud University Nijmegen),
Wouter de Munter4
Estimated H-index: 4
(Radboud University Nijmegen)
+ 8 AuthorsA.B. Blom29
Estimated H-index: 29
(Radboud University Nijmegen)
Objective Alarmins S100A8 and S100A9 are major products of activated macrophages regulating cartilage damage and synovial activation during murine and human osteoarthritis (OA). In the current study, we investigated whether S100A8 and S100A9 are involved in osteophyte formation during experimental OA and whether S100A8/A9 predicts osteophyte progression in early human OA. Methods OA was elicited in S100A9−/− mice in two experimental models that differ in degree of synovial activation. Osteophyte...
Published on Dec 1, 2015in BMC Medicine8.29
Carmelo Scarpignato34
Estimated H-index: 34
(University of Parma),
Estimated H-index: 46
(University of Zaragoza)
+ 3 AuthorsRichard H. Hunt68
Estimated H-index: 68
(McMaster University)
Background: There are several guidelines addressing the issues around the use of NSAIDs. However, none has specifically addressed the upper versus lower gastrointestinal (GI) risk of COX-2 selective and non-selective compounds nor the interaction at both the GI and cardiovascular (CV) level of either class of drugs with low-dose aspirin. This Consensus paper aims to develop statements and guidance devoted to these specific issues through a review of current evidence by a multidisciplinary group ...
Published on Nov 1, 2015in Osteoarthritis and Cartilage4.88
B Guo1
Estimated H-index: 1
(University of Manchester),
Nan Yang8
Estimated H-index: 8
(University of Manchester)
+ 10 AuthorsJohn F. Bateman49
Estimated H-index: 49
Summary Objective To define how the catabolic cytokines (Interleukin 1 (IL-1) and tumor necrosis factor alpha (TNFα)) affect the circadian clock mechanism and the expression of clock-controlled catabolic genes within cartilage, and to identify the downstream pathways linking the cytokines to the molecular clock within chondrocytes. Methods Ex vivo cartilage explants were isolated from the Cry1 -luc or PER2::LUC clock reporter mice. Clock gene dynamics were monitored in real-time by bioluminescen...
Published on Sep 1, 2015in British Medical Bulletin2.80
S Kluzek6
Estimated H-index: 6
(University of Oxford),
J L Newton14
Estimated H-index: 14
(University of Oxford),
N K Arden65
Estimated H-index: 65
(University of Oxford)
Background: Obesity is associated with an increased risk of developing osteoarthritis (OA), even in non-weight bearing joints. High levels of adipose tissue-associated inflammation may explain this association. Sources of data and areas of debate: Published evidence looking at the associations between components of Metabolic Syndrome (MetS) and knee, hip or hand OA and the higher mortality described with knee OA. Emerging points: Development of MetS and OA shares a relationship with adipose tiss...
Published on Sep 1, 2015in Journal of Cellular Physiology4.52
Ranjan Kc8
Estimated H-index: 8
(Rush University Medical Center),
Xin Li17
Estimated H-index: 17
(Rush University Medical Center)
+ 11 AuthorsGary S. Stein105
Estimated H-index: 105
(UVM: University of Vermont)
Circadian rhythm dysfunction is linked to many diseases, yet pathophysiological roles in articular cartilage homeostasis and degenerative joint disease including osteoarthritis (OA) remains to be investigated in vivo. Here, we tested whether environmental or genetic disruption of circadian homeostasis predisposes to OA-like pathological changes. Male mice were examined for circadian locomotor activity upon changes in the light:dark (LD) cycle or genetic disruption of circadian rhythms. Wild-type...
Cited By116
Published on Dec 4, 2019in Artificial Cells Nanomedicine and Biotechnology4.46
Xiaoyan Li1
Estimated H-index: 1
(Jining Medical University),
Manqiu Yu1
Estimated H-index: 1
+ 5 AuthorsTaitao Sun1
Estimated H-index: 1
(Jining Medical University)
AbstractBackground: The anti-inflammatory function of microRNA-124 (miR-124) has been a matter of extensive studies in the last few years. Although LINC00305 regulates biological activities by acting as a miR sponge, it is still unexplored whether LINC00305 is involved in inflammation by regulating miR-124.Methods: Cell viability and apoptosis were evaluated with commercial kits, cell counting kit-8 (CCK-8) and Annexin V-fluorescein isothiocyanate (FITC) kit, respectively. LINC00305, miR-124 and...
Published on Feb 20, 2019in Bone research
Chuangxin Lin1
Estimated H-index: 1
(Southern Medical University),
Liangliang Liu1
Estimated H-index: 1
(Southern Medical University)
+ 11 AuthorsRongkai Zhang1
Estimated H-index: 1
(Southern Medical University)
Increasing evidences show that aberrant subchondral bone remodeling plays an important role in the development of osteoarthritis (OA). However, how subchondral bone formation is activated and the mechanism by which increased subchondral bone turnover promotes cartilage degeneration during OA remains unclear. Here, we show that the mechanistic target of rapamycin complex 1 (mTORC1) pathway is activated in subchondral bone preosteoblasts (Osterix+) from OA patients and mice. Constitutive activatio...
Published on Dec 1, 2019in Journal of Inflammation2.66
Qihong Que , Xinghua Guo + 5 AuthorsShuanglin Wan (SRRSH: Sir Run Run Shaw Hospital)
Background Inflammation is a common pathological phenomenon of osteoarthritis (OA). Accumulated evidence indicates that ameliorating or suppressing inflammation might be a promising and effective therapeutic strategy for the treatment of OA. Notably, glucagon-like peptide-1 (GLP-1)-based drugs are being successfully used to control glucose levels in patients with diabetes mellitus. In addition, recent findings have indicated that GLP-1 agonists, such as liraglutide have therapeutic potential in ...
Published on Nov 1, 2019in Ageing Research Reviews10.39
Emmanuel Biver18
Estimated H-index: 18
(University of Geneva),
Francis Berenbaum52
Estimated H-index: 52
(University of Paris)
+ 19 AuthorsAntonio Cherubini59
Estimated H-index: 59
Abstract The prevalence of osteoarthritis (OA) increases not only because of longer life expectancy but also because of the modern lifestyle, in particular physical inactivity and diets low in fiber and rich in sugar and saturated fats, which promote chronic low-grade inflammation and obesity. Adverse alterations of the gut microbiota (GMB) composition, called microbial dysbiosis, may favor metabolic syndrome and inflammaging, two important components of OA onset and evolution. Considering the b...
Published on Oct 17, 2018in Arthritis Care and Research4.53
Elizabeth M. Badley3
Estimated H-index: 3
(U of T: University of Toronto),
Margot Shields3
Estimated H-index: 3
(Public Health Agency of Canada)
+ 2 AuthorsLil Tonmyr19
Estimated H-index: 19
(Public Health Agency of Canada)
Published on Jun 25, 2019in Biological Research For Nursing1.51
Alisha Hackney1
Estimated H-index: 1
(UMD: University of Maryland, College Park),
N. Jennifer Klinedinst4
Estimated H-index: 4
(UMD: University of Maryland, College Park)
+ 1 AuthorsMeg Johantgen17
Estimated H-index: 17
(UMD: University of Maryland, College Park)
Published on Apr 1, 2019in Trends in Biotechnology13.75
Susanna Piluso (UT: University of Twente), Yang Li (UU: Utrecht University)+ 6 AuthorsJos Malda43
Estimated H-index: 43
(UU: Utrecht University)
Treating joint diseases remains a significant clinical challenge. Conventional in vitro cultures and animal models have been helpful, but suffer from limited predictive power for the human response. Advanced models are therefore required to mimic the complex biological interactions within the human joint. However, the intricate structure of the joint microenvironment and the complex nature of joint diseases have challenged the development of in vitro models that can faithfully mimic the in vivo ...
Published on Sep 23, 2019in International Journal of Molecular Sciences4.18
Cleydlenne C. Vasconcelos1
Estimated H-index: 1
Alberto J. O. Lopes3
Estimated H-index: 3
+ 6 AuthorsMaria do Socorro de S. Cartágenes5
Estimated H-index: 5
The aim of this study was to analyze the analgesic potential of Arrabidaea chica extract (EHA) as an alternative to osteoarthritis (OA) treatment. Thus, the extract was initially evaluated by the cyclooxygenase inhibition test. The analgesic effect of the extract, in vivo, was also verified in a model of OA induced by sodium monoiodoacetate (2 mg). EHA was administered to rats at doses of 50, 150, and 450 mg/kg between 3 and 25 days after OA induction. The animals were clinically evaluated every...