The effects of prenatal metformin on obesogenic diet-induced alterations in maternal and fetal fatty acid metabolism
Abstract
Maternal obesity may program the fetus and increase the susceptibility of the offspring to adult diseases. Metformin crosses the placenta and has been associated with decreased inflammation and reversal of fatty liver in obese leptin-deficient mice. We investigated the effects of metformin on maternal and fetal lipid metabolism and hepatic inflammation using a rat model of diet-induced obesity during pregnancy.Female Wistar rats (6-7 weeks old)...
Paper Details
Title
The effects of prenatal metformin on obesogenic diet-induced alterations in maternal and fetal fatty acid metabolism
Published Date
Aug 22, 2016
Journal
Volume
13
Issue
1
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