Renal Denervation Reverses Hepatic Insulin Resistance Induced by High-Fat Diet
Abstract
Activation of the sympathetic nervous system (SNS) constitutes a putative mechanism of obesity-induced insulin resistance. Thus, we hypothesized that inhibiting the SNS by using renal denervation (RDN) will improve insulin sensitivity (SI) in a nonhypertensive obese canine model. SI was measured using euglycemic-hyperinsulinemic clamp (EGC), before (week 0 [w0]) and after 6 weeks of high-fat diet (w6-HFD) feeding and after either RDN (HFD + RDN)...
Paper Details
Title
Renal Denervation Reverses Hepatic Insulin Resistance Induced by High-Fat Diet
Published Date
Aug 5, 2016
Journal
Volume
65
Issue
11
Pages
3453 - 3463
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