A prognostic predictor panel with DNA methylation biomarkers for early-stage lung adenocarcinoma in Asian and Caucasian populations

Published on Dec 1, 2016in Journal of Biomedical Science5.203
路 DOI :10.1186/s12929-016-0276-x
I-Ying Kuo6
Estimated H-index: 6
(NCKU: National Cheng Kung University),
Jayu Jen6
Estimated H-index: 6
(NCKU: National Cheng Kung University)
+ 3 AuthorsYi-Ching Wang28
Estimated H-index: 28
(NCKU: National Cheng Kung University)
Background The incidence of lung adenocarcinoma (LUAD) is increasing worldwide with different prognosis even in early-stage patients. We aimed to identify a prognostic panel with multiple DNA methylation biomarkers to predict survival in early-stage LUAD patients of different racial groups.
  • References (32)
  • Citations (3)
馃摉 Papers frequently viewed together
5 Citations
137 Citations
13 Citations
78% of Scinapse members use related papers. After signing in, all features are FREE.
#1Ana I. Robles (NIH: National Institutes of Health)H-Index: 39
#2Eri AraiH-Index: 19
Last. Curtis C. Harris (NIH: National Institutes of Health)H-Index: 132
view all 22 authors...
Introduction: Up to 30% stage I lung cancer patients suffer recurrence within 5 years of curative surgery. We sought to improve existing protein-coding gene and microRNA expression prognostic classifiers by incorporating epigenetic biomarkers. Methods: Genome-wide screening of DNA methylation and pyrosequencing analysis of HOXA9 promoter methylation were performed in two independently collected cohorts of stage I lung adenocarcinoma. The prognostic value of HOXA9 promoter methylation alone and i...
45 CitationsSource
#1Lynne ForrestH-Index: 7
#2Jean AdamsH-Index: 32
Last. Gregory P. RubinH-Index: 20
view all 4 authors...
Factors associated with timeliness of post-primary care referral, diagnosis and treatment for lung cancer: population-based, data-linkage study
19 CitationsSource
#1Ruyang Zhang (Nanjing Medical University)H-Index: 11
#2Minjie Chu (Nanjing Medical University)H-Index: 17
Last. Feng Chen (Nanjing Medical University)H-Index: 28
view all 21 authors...
Tobacco smoke is the major environmental risk factor underlying lung carcinogenesis. However, approximately one-tenth smokers develop lung cancer in their lifetime indicating there is significant individual variation in susceptibility to lung cancer. And, the reasons for this are largely unknown. In particular, the genetic variants discovered in genome-wide association studies (GWAS) account for only a small fraction of the phenotypic variations for lung cancer, and gene鈥揺nvironment interactions...
23 CitationsSource
The field of epigenetics has exploded in the last two decades, with incredible advances in recent years driven by high-throughput sequencing studies. Cancer cells frequently exhibit marked changes in DNA methylation and histone modification during tumorigenesis and tumor progression. These changes in the cancer epigenome are thought to be important in initiating and maintaining malignancy, and pharmaceutical approaches targeting epigenome-modifying enzymes are an attractive therapeutic strategy....
28 CitationsSource
#1Juan SandovalH-Index: 26
Last. Manel Esteller (University of Barcelona)H-Index: 128
view all 31 authors...
137 CitationsSource
#1Yong-June Kim (CBNU: Chungbuk National University)H-Index: 18
#2Hyung-Yoon Yoon (CBNU: Chungbuk National University)H-Index: 6
Last. W.J. Kim (CBNU: Chungbuk National University)H-Index: 38
view all 11 authors...
DNA methylation patterns are associated with the development and prognosis of cancer. The aim of this study was to identify novel methylation markers for the prediction of patient outcomes using microarray analysis of DNA methylation and RNA expression patterns in samples from long-term follow-up patients with nonmuscle invasive bladder cancer (NMIBC). A total of 187 human bladder specimens were used for microarray array or pyrosequencing (PSQ) analyses: 6 normal controls (NC) and 181 NMIBC. Tum...
56 CitationsSource
#1Xiaotu Ma (UTD: University of Texas at Dallas)H-Index: 18
#2Yi Wei Wang (UTSW: University of Texas Southwestern Medical Center)H-Index: 3
Last. Adi F. GazdarH-Index: 142
view all 4 authors...
With the rapid development of genome-wide high-throughput technologies, including expression arrays, SNP arrays and next-generation sequencing platforms, enormous amounts of molecular data have been generated and deposited in the public domain. The application of computational approaches is required to yield biological insights from this enormous, ever-growing resource. A particularly interesting subset of these resources is related to epigenetic regulation, with DNA methylation being the most a...
51 CitationsSource
#1Gerwin HellerH-Index: 19
#2Valerie BabinskyH-Index: 2
view all 22 authors...
DNA methylation is part of the epigenetic gene regulation complex, which is relevant for the pathogenesis of cancer. We performed a genome-wide search for methylated CpG islands in tumors and corresponding non-malignant lung tissue samples of 101 stages IIII non-small cell lung cancer (NSCLC) patients by combining methylated DNA immunoprecipitation and microarray analysis. Overall, we identified 2414 genomic positions differentially methylated between tumor and non-malignant lung tissue samples....
39 CitationsSource
#1Jaehyung ParkH-Index: 30
#2Donghwa KimH-Index: 1
Last. Seung Joon Kim (Catholic University of Korea)H-Index: 15
view all 11 authors...
Background Aberrant DNA hypermethylation has been implicated as a component of an epigenetic mechanism that silences genes in cancers.
15 CitationsSource
#1Rebecca L. Siegel (ACS: American Cancer Society)H-Index: 47
#2Deepa Naishadham (ACS: American Cancer Society)H-Index: 22
Last. Ahmedin Jemal (ACS: American Cancer Society)H-Index: 106
view all 3 authors...
Each year, the American Cancer Society estimates the numbers of new cancer cases and deaths expected in the United States in the current year and compiles the most recent data on cancer incidence, mortality, and survival based on incidence data from the National Cancer Institute, the Centers for Disease Control and Prevention, and the North American Association of Central Cancer Registries and mortality data from the National Center for Health Statistics. A total of 1,660,290 new cancer cases an...
8,621 CitationsSource
Cited By3
#1Christina U. K枚hler (RUB: Ruhr University Bochum)H-Index: 6
#2Nadine Bonberg (RUB: Ruhr University Bochum)H-Index: 9
Last. Thomas Br眉ning (RUB: Ruhr University Bochum)H-Index: 51
view all 20 authors...
#1Fei Yuan (Binzhou University)H-Index: 1
#2Wencong Lu (SHU: Shanghai University)H-Index: 23
Abstract Lung cancer is a serious disease that threatens an affected individual's life. Its pathogenesis has not yet to be fully described, thereby impeding the development of effective treatments and preventive measures. 鈥淐ancer driver鈥 theory considers that tumor initiation can be associated with a number of specific mutations in genes called cancer driver genes. Four omics levels, namely, (1) methylation, (2) microRNA, (3) mutation, and (4) mRNA levels, are utilized to cluster cancer driver g...
7 CitationsSource
#1Haidan Yan (Fujian Medical University)H-Index: 1
#2Qingzhou Guan (Fujian Medical University)H-Index: 8
Last. Fei He (Fujian Medical University)H-Index: 1
view all 10 authors...
Background Due to the heterogeneity of cancer, identifying differentially methylated (DM) CpG sites between a set of cancer samples and a set of normal samples cannot tell us which patients have methylation aberrations in a particular DM CpG site.
7 CitationsSource