Etiology, Pathogenesis and Pathophysiology of Aortic Aneurysms and Aneurysm Rupture

Published on Jul 27, 2011
· DOI :10.5772/995
Reinhart Grundmann1
Estimated H-index: 1
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  • Citations (9)
Cited By9
#1Markus WortmannH-Index: 4
#2K. MeisenbacherH-Index: 5
Last. D. BöcklerH-Index: 5
view all 6 authors...
#1Katarzyna Grzela (Medical University of Warsaw)H-Index: 6
#2Wioletta Zagórska (Medical University of Warsaw)H-Index: 5
Last. Tomasz Grzela (Medical University of Warsaw)H-Index: 17
view all 8 authors...
The airway remodeling in asthma is associated with increased amount of matrix metalloproteinase (MMP)-9. High levels of MMP-9 were found in mucosal biopsies, sputum and in exhaled breath condensates (EBC) of asthma patients. However, there are no data concerning real in vivo activity. Inhaled corticosteroids are effective in asthma control, but it is unclear, whether they only attenuate inflammation, or also protect against progressive remodeling of respiratory tract. Therefore, the aim of the s...
13 CitationsSource
#1Romy FrankenH-Index: 13
#2Teodora Radonic (VU: VU University Amsterdam)H-Index: 13
Last. V. de WaardH-Index: 2
view all 10 authors...
Background Recently, we demonstrated that losartan reduced the aortic root dilatation rate (AoDR) in adults with Marfan syndrome (MFS); however, responsiveness was diverse. The aim was to determine the role of transforming growth factor-β (TGF-β) as therapeutic biomarker for effectiveness of losartan on AoDR.
19 CitationsSource
#1Ana García-Martínez (University of Barcelona)H-Index: 23
#2Pedro Arguis (University of Barcelona)H-Index: 14
Last. Maria C. Cid (University of Barcelona)H-Index: 51
view all 9 authors...
Background Aortic structural damage (ASD) may complicate the course of patients with giant cell arteritis (GCA). However the frequency and outcome of ASD has not been assessed in long term prospective studies. Methods In a previous screening of 54 biopsy proven GCA patients, significant ASD was detected in 12 (22.2%) after a median follow-up of 5.4 years. These patients were periodically evaluated (every 4 years) over a median of 10.3 years (range 4–16.6 years) in order to investigate the develo...
56 CitationsSource
#1Sonaz Malekzadeh (EPFL: École Polytechnique Fédérale de Lausanne)H-Index: 2
#2Rodrigo A. Fraga-Silva (EPFL: École Polytechnique Fédérale de Lausanne)H-Index: 23
Last. Nikolaos Stergiopulos (EPFL: École Polytechnique Fédérale de Lausanne)H-Index: 49
view all 6 authors...
BackgroundAbdominal aortic aneurysm (AAA) is a complex degenerative disease, which leads to morbidity and mortality in a large portion of the elderly population. Current treatment options for AAA are quite limited as there is no proven indication for pharmacological therapy and surgery is recommended for AAA larger than 55cm in luminal diameter. Thus, there is a great need to elucidate the underlying pathophysiological cellular and molecular mechanisms to develop effective therapies. In this nar...
19 CitationsSource
#1Chek Kun Tan (NTU: Nanyang Technological University)H-Index: 18
#2Eddie Han Pin Tan (NTU: Nanyang Technological University)H-Index: 6
Last. Nguan Soon Tan (NTU: Nanyang Technological University)H-Index: 45
view all 7 authors...
BackgroundNinety percent of the patients carrying distinct SMAD3 mutations develop aortic aneurysms and dissections, called aneurysms‐osteoarthritis syndrome (AOS). However, the etiology and molecular events downstream of SMAD3 leading to the pathogenesis of aortic aneurysms in these patients still remain elusive. Therefore, we aimed to investigate the vascular phenotypes of SMAD 3‐knockout mice. Methods and ResultsWe have shown that angiotensin II–induced vascular inflammation, but not hyperten...
25 CitationsSource
#1Jie Zhang (Brigham and Women's Hospital)H-Index: 12
#2Huimei Chen (NU: Nanjing University)H-Index: 4
Last. Guo-Ping Shi (Brigham and Women's Hospital)H-Index: 61
view all 7 authors...
Aims Mast cells participate importantly in abdominal aortic aneurysms (AAAs) by releasing inflammatory cytokines to promote vascular cell protease expression and arterial wall remodelling. Mast cells accumulate in AAA lesions during disease progression, but the exact chemokines by which mast cells migrate to the site of vascular inflammation remain unknown. This study tested the hypothesis that mast cells use chemokine (C-C motif) receptor 2 (CCR2) for their accumulation in experimental mouse AA...
11 CitationsSource
Objective— The mechanisms underlying abdominal aortic aneurysm development remain unknown. We hypothesized that acceleration of glucose metabolism with the upregulation of glucose transporters is associated with abdominal aortic aneurysm development. Methods and Results— Enhanced accumulation of the modified glucose analogue 18 fluoro-deoxyglucose by positron emission tomography imaging in the human abdominal aortic aneurysm was associated with protein expressions of glucose transporters-1 and -...
18 CitationsSource