Improved DNA binding specil finger peptides by using strir two-finger units

Multizinc finger peptides are likely to reach increased prominence trn in the search for the ideal designer transcription factor for in vivo an applications such as gene therapy. However, for these treatments th to be effective and safe, the peptides must bind with high affinity in and, more importantly, with great specificity. Our previous retw search has shown that zinc finger arrays can be made to bind 18 bp gr of DNA with picomolar affinity,...