The 5A apolipoprotein A‐I (apoA‐I) mimetic peptide ameliorates experimental colitis by regulating monocyte infiltration

Background and Purpose New therapies for inflammatory bowel disease (IBD) are highly desirable. As apolipoprotein (apo)A‐I mimetic peptides are beneficial in several animal models of inflammation, we hypothesized that they might be effective at inhibiting murine colitis. Experimental Approach Daily injections of 5A peptide, a synthetic bihelical apoA‐I mimetic dissolved in PBS, or PBS alone were administered to C57BL/6 mice fed 3% (w v ‐1 )...