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Effects of diet composition on weight loss, metabolic factors and biomarkers in a 1-year weight loss intervention in obese women examined by baseline insulin resistance status

Published on Nov 1, 2016in Metabolism-clinical and Experimental6.51
· DOI :10.1016/j.metabol.2016.07.008
Cheryl L. Rock81
Estimated H-index: 81
(UCSD: University of California, San Diego),
Shirley W. Flatt42
Estimated H-index: 42
(UCSD: University of California, San Diego)
+ 4 AuthorsLoki Natarajan46
Estimated H-index: 46
(UCSD: University of California, San Diego)
Abstract
Abstract Background Obesity is a risk factor for postmenopausal breast cancer incidence and premenopausal and postmenopausal breast cancer mortality, which may be explained by several metabolic and hormonal factors (sex hormones, insulin resistance, and inflammation) that are biologically related. Differential effects of dietary composition on weight loss and these metabolic factors may occur in insulin-sensitive vs. insulin-resistant obese women. Objective To examine the effect of diet composition on weight loss and metabolic, hormonal and inflammatory factors in overweight/obese women stratified by insulin resistance status in a 1-year weight loss intervention. Methods and Results Nondiabetic women who were overweight/obese (n = 245) were randomly assigned to a lower fat (20% energy), higher carbohydrate (65% energy) diet; a lower carbohydrate (45% energy), higher fat (35% energy) diet; or a walnut-rich (18% energy), higher fat (35% energy), lower carbohydrate (45% energy) diet. All groups lost weight at follow-up (P  Conclusions Findings provide some support for differential effects of diet composition on weight loss depending on insulin resistance status. Prescribing walnuts is associated with weight loss comparable to a standard lower fat diet in a behavioral weight loss intervention. Weight loss itself may be the most critical factor for reducing the chronic inflammation associated with increased breast cancer risk and progression.
  • References (42)
  • Citations (22)
References42
Newest
#1Tran Le (UCSD: University of California, San Diego)H-Index: 1
#2Shirley W. Flatt (UCSD: University of California, San Diego)H-Index: 42
Last.Cheryl L. Rock (UCSD: University of California, San Diego)H-Index: 81
view all 8 authors...
#1David Baer (ARS: Agricultural Research Service)H-Index: 39
#2Sarah K Gebauer (ARS: Agricultural Research Service)H-Index: 7
Last.Janet A. Novotny (ARS: Agricultural Research Service)H-Index: 24
view all 3 authors...
#1Claire Cleland (Glas.: University of Glasgow)H-Index: 5
#2Ruth F. Hunter ('QUB': Queen's University Belfast)H-Index: 15
Last.Mark Tully ('QUB': Queen's University Belfast)H-Index: 21
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Cited By22
Newest
#1Ross L. Prentice (Fred Hutchinson Cancer Research Center)H-Index: 90
#2Aaron K. Aragaki (Fred Hutchinson Cancer Research Center)H-Index: 43
Last.Lewis E Kuller (University of Pittsburgh)
view all 14 authors...
#1Selene Yue Xu (UCSD: University of California, San Diego)H-Index: 1
#2Sandahl H. Nelson (SDSU: San Diego State University)H-Index: 6
Last.Loki Natarajan (UCSD: University of California, San Diego)H-Index: 46
view all 10 authors...
#1Eleni Pilitsi (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 1
#2Olivia M. Farr (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 19
Last.Christos S. Mantzoros (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 103
view all 7 authors...
#1Alyssa M. Tindall (PSU: Pennsylvania State University)H-Index: 1
#2Emily Johnston (PSU: Pennsylvania State University)H-Index: 1
Last.Kristina S. Petersen (PSU: Pennsylvania State University)H-Index: 9
view all 4 authors...
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