Review paper
Regulation of Single-Strand Annealing and its Role in Genome Maintenance
Abstract
Single-strand annealing (SSA) is a DNA double-strand break (DSB) repair pathway that uses homologous repeats to bridge DSB ends. SSA involving repeats that flank a single DSB causes a deletion rearrangement between the repeats, and hence is relatively mutagenic. Nevertheless, this pathway is conserved, in that SSA events have been found in several organisms. In this review, we describe the mechanism of SSA and its regulation, including the...
Paper Details
Title
Regulation of Single-Strand Annealing and its Role in Genome Maintenance
Published Date
Sep 1, 2016
Journal
Volume
32
Issue
9
Pages
566 - 575
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