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References914
Newest
Published on Jul 1, 2010in Current Aging Science
Sofia Rodriguez4
Estimated H-index: 4
,
Maria Eriksson36
Estimated H-index: 36
The molecular mechanisms that cause physiological aging are still not completely understood, most likely because of the complex nature of the aging process. Recent discoveries on segmental progeroid syndromes emphasize the importance of studying rare diseases to discover more common mechanisms. Since the identification of mutations in the LMNA gene that causes the segmental progeroid syndrome, Hutchinson-Gilford progeria syndrome (HGPS), there has been an increasing interest in the potential rol...
Published on Jul 1, 2010in Clinical and Experimental Dermatology1.77
E. Cutillas1
Estimated H-index: 1
,
F. J. Ferrando1
Estimated H-index: 1
+ 2 AuthorsN. Rausell1
Estimated H-index: 1
Summary Mid-dermal elastolysis is an unusual process characterized by the absence of the elastic fibres within the mid-dermis. The disappearance of these fibres causes fine wrinkles (type 1) or perifollicular protrusions (type 2) affecting the trunk, neck and arms. There is a female predilection, and most patients have a history of intense sun exposure. Recently, some cases of mid-dermal elastolysis presenting as reticular erythema have been reported. We report a case of reticular erythema with ...
Published on Jun 1, 2010in Journal of Investigative Dermatology6.29
Christian Calles9
Estimated H-index: 9
,
Maren Schneider4
Estimated H-index: 4
+ 3 AuthorsPeter Schroeder25
Estimated H-index: 25
Infrared A (IRA) radiation (760–1440nm) is a major component of solar radiation and, similar to UVR, causes photoaging of human skin by increasing the expression of matrix metalloproteinase-1 in human skin fibroblasts. In this study, we assessed the IRA-induced transcriptome in primary human skin fibroblasts. Microarray analysis revealed 599 IRA-regulated transcripts. The IRA-induced transcriptome differed from changes known to be induced by UV. IRA-responsive genes include the categories extrac...
Published on May 1, 2010in Journal of Investigative Dermatology6.29
Qiujie Jiang23
Estimated H-index: 23
(Thomas Jefferson University),
Florian Dibra5
Estimated H-index: 5
(Thomas Jefferson University)
+ 2 AuthorsJouni Uitto94
Estimated H-index: 94
(Thomas Jefferson University)
The pathologic hallmark of pseudoxanthoma elasticum (PXE) is ectopic mineralization of soft connective tissues. Recent studies have suggested that PXE is a metabolic disease, and perturbations in a number of circulatory factors have been postulated. One of them is fetuin-A, a 60-kDa glycoprotein synthesized in the liver and secreted into blood. Observations in targeted mutant mice ( Ahsg −/− ) and in cell culture model systems have shown that fetuin-A is a powerful anti-mineralization factor in ...
Published on Apr 1, 2010in British Journal of Oral & Maxillofacial Surgery1.16
Sudeendra Prabhu2
Estimated H-index: 2
,
K.P. Mahesh1
Estimated H-index: 1
Tuberous sclerosis is a multisystem disorder characterised by the formation of hamartomas in various parts of the body. We present a patient who presented with facial angiofibromas (adenoma sebaceum), shagreen patches, and epileptic seizures. Oral papules showed histological features of angiofibroma, which was peculiar to this case.
Published on Apr 1, 2010in Supportive Care in Cancer2.75
Mario E. Lacouture46
Estimated H-index: 46
,
Michael L. Maitland25
Estimated H-index: 25
(U of C: University of Chicago)
+ 17 AuthorsLynne I. Wagner33
Estimated H-index: 33
(NU: Northwestern University)
Background Accurate grading of dermatologic adverse events (AE) due to epidermal growth factor receptor (EGFR) inhibitors (EGFRIs) is necessary for drug toxicity determinations, interagent comparisons, and supportive care trials. The most widely used severity grading scale, the National Cancer Institute’s Common Terminology Criteria for Adverse Events version 4.0 (NCI-CTCAE v4.0), was not designed specifically for this class of agents and may result in underreporting and poor grading of distinct...
Published on Mar 1, 2010in Journal of Investigative Dermatology6.29
Jouni Uitto94
Estimated H-index: 94
(Thomas Jefferson University),
Qiaoli Li22
Estimated H-index: 22
(Thomas Jefferson University),
Qiujie Jiang23
Estimated H-index: 23
(Thomas Jefferson University)
Pseudoxanthoma elasticum (PXE), a prototypic heritable disorder with ectopic mineralization, manifests with characteristic skin findings, ocular involvement and cardiovascular problems, with considerable morbidity and mortality. The classic forms of PXE are due to loss-of-function mutations in the ABCC6 gene, which encodes ABCC6, a transmembrane efflux transporter expressed primarily in the liver. Several lines of evidence suggest that PXE is a primary metabolic disorder, which in the absence of...
Published on Mar 1, 2010in Rheumatology International2.20
Cemal Bes8
Estimated H-index: 8
(Abant Izzet Baysal University),
Şeref Vardı2
Estimated H-index: 2
(Abant Izzet Baysal University)
+ 1 AuthorsMehmet Soy15
Estimated H-index: 15
(Abant Izzet Baysal University)
Werner’s syndrome (WS) is an autosomal recessive disorder characterized by premature aging. The main features of the disease are scleroderma-like skin appearance, premature atherosclerosis, short stature, diabetes mellitus, early osteoporosis and early aging. Herein, we describe a patient with WS, who has scleroderma-like skin changes and discuss the literature about WS as a disease in the differential diagnosis of systemic sclerosis.
Published on Mar 1, 2010in American Journal of Medical Genetics Part A2.20
Marco Castori27
Estimated H-index: 27
,
Filippo Camerota23
Estimated H-index: 23
(Sapienza University of Rome)
+ 4 AuthorsPaola Grammatico32
Estimated H-index: 32
Hypermobility type Ehlers–Danlos syndrome (HT-EDS) is a relatively frequent, although commonly misdiagnosed variant of Ehlers–Danlos syndrome, mainly characterized by marked joint instability and mild cutaneous involvement. Chronic pain, asthenia, and gastrointestinal and pelvic dysfunction are characteristic additional manifestations. We report on 21 HT-EDS patients selected from a group of 40 subjects with suspected mild hereditary connective tissue disorder. General, mucocutaneous, musculoske...
Published on Mar 1, 2010in Archives of Dermatological Research2.31
Thilo Gambichler45
Estimated H-index: 45
(RUB: Ruhr University Bochum)
The clinical as well as histological data of 79 mid-dermal elastolysis (MDE) patients reported in the literature were evaluated. MDE is an acquired skin condition of the elastic tissue predominantly manifesting on the trunk and proximal extremities of young women. Most commonly observed skin changes include patches of well-circumscribed fine wrinkles (type I) and perifollicular papular protrusions (type II). Rarely, MDE may also occur with persistent reticular erythema and wrinkling (type III). ...
Cited By3
Newest
Published on Mar 1, 2015in JAAD case reports
William C. Schaffenburg1
Estimated H-index: 1
(Tripler Army Medical Center),
Colby Fernelius2
Estimated H-index: 2
(Tripler Army Medical Center),
Navin S. Arora2
Estimated H-index: 2
(Tripler Army Medical Center)
First reported in 1928, Buschke-Ollendorff syndrome (BOS) is an autosomal dominant genodermatosis with high penetrance and variable expressivity. It is characterized by skin-colored or yellow smooth papules, plaques, and nodules up to 2 cm consisting of elastomas or collagenomas, known as dermatofibrosis lenticularis disseminata.1 This syndrome also has nearly pathognomonic radiographic findings of 1- to 10-mm spherical, radiopaque osteosclerotic foci with uneven contours at the epiphysis and me...
Published on Sep 1, 2011in British Journal of Radiology1.94
R C U Priyadarshika1
Estimated H-index: 1
,
Jeffrey C. Crosbie11
Estimated H-index: 11
+ 1 AuthorsPeter Rogers52
Estimated H-index: 52
Objectives: Microbeam radiotherapy (MRT) with wafers of microscopically narrow, synchrotron generated X-rays is being used for pre-clinical cancer trials in animal models. It has been shown that high dose MRT can be effective at destroying tumours in animal models, while causing unexpectedly little damage to normal tissue. The aim of this study was to use a dermatopathological scoring system to quantify and compare the acute biological response of normal mouse skin with microplanar and broad-bea...
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