GPR91 senses extracellular succinate released from inflammatory macrophages and exacerbates rheumatoid arthritis

Volume: 213, Issue: 9, Pages: 1655 - 1662
Published: Aug 22, 2016
Abstract
When SUCNR1/GPR91-expressing macrophages are activated by inflammatory signals, they change their metabolism and accumulate succinate. In this study, we show that during this activation, macrophages release succinate into the extracellular milieu. They simultaneously up-regulate GPR91, which functions as an autocrine and paracrine sensor for extracellular succinate to enhance IL-1β production. GPR91-deficient mice lack this metabolic sensor and...
Paper Details
Title
GPR91 senses extracellular succinate released from inflammatory macrophages and exacerbates rheumatoid arthritis
Published Date
Aug 22, 2016
Volume
213
Issue
9
Pages
1655 - 1662
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