p53 coordinates decidual sestrin 2/AMPK/mTORC1 signaling to govern parturition timing
Volume: 126, Issue: 8, Pages: 2941 - 2954
Published: Jul 25, 2016
Abstract
Inflammation and oxidative stress are known risk factors for preterm birth (PTB); however, the mechanisms and pathways that influence this condition are not fully described. Previously, we showed that mTORC1 signaling is increased in mice harboring a uterine-specific deletion of transformation-related protein 53 (p53d/d mice), which exhibit premature decidual senescence that triggers spontaneous and inflammation-induced PTB. Treatment with the...
Paper Details
Title
p53 coordinates decidual sestrin 2/AMPK/mTORC1 signaling to govern parturition timing
Published Date
Jul 25, 2016
Volume
126
Issue
8
Pages
2941 - 2954
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