SIRT1 Mediates Depression-Like Behaviors in the Nucleus Accumbens
Abstract
Depression is a recurring and life-threatening illness that affects up to 120 million people worldwide. In the present study, we show that chronic social defeat stress, an ethologically validated model of depression in mice, increases SIRT1 levels in the nucleus accumbens (NAc), a key brain reward region. Increases in SIRT1, a well characterized class III histone deacetylase, after chronic social defeat suggest a role for this enzyme in...
Paper Details
Title
SIRT1 Mediates Depression-Like Behaviors in the Nucleus Accumbens
Published Date
Aug 10, 2016
Journal
Volume
36
Issue
32
Pages
8441 - 8452
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