DNA Repair Profiling Reveals Nonrandom Outcomes at Cas9-Mediated Breaks

Volume: 63, Issue: 4, Pages: 633 - 646
Published: Aug 18, 2016
Abstract
Summary null The repair outcomes at site-specific DNA double-strand breaks (DSBs) generated by the RNA-guided DNA endonuclease Cas9 determine how gene function is altered. Despite the widespread adoption of CRISPR-Cas9 technology to induce DSBs for genome engineering, the resulting repair products have not been examined in depth. Here, the DNA repair profiles of 223 sites in the human genome demonstrate that the pattern of DNA repair following...
Paper Details
Title
DNA Repair Profiling Reveals Nonrandom Outcomes at Cas9-Mediated Breaks
Published Date
Aug 18, 2016
Volume
63
Issue
4
Pages
633 - 646
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