Long-Chain Fatty Acids Regulate GnRH Receptor mRNA Expression Level in the Gonadotrope of the Mouse Anterior Pituitary Gland.

Free Fatty acids are not only energy fuels but also signaling molecules. In fact, long-chain fatty acids (LCFAs) have been identified as the ligands for G protein-coupled receptor 120 (GPR120). We have previously observed that GPR120 is richly expressed in the gonadotropes of the mouse anterior pituitary gland and 48hr fasting induces increase in GPR120 mRNA level in the mouse pituitary. Further, in circadian variations, GPR120 mRNA expression...