Sequence Alterations in the Carboxyl-Terminal Propeptide Domain

Pages: 129 - 140
Published: Jan 1, 2014
Abstract
Mutations in the carboxyl-terminal propeptides (C-propeptides) of either the proα1(I) or the proα2(I) collagen chain are rare, but demonstrate the critical role of these regions in directing chain recognition, assembly and initiation of helix formation. In general C-propeptide mutations that completely prevent incorporation of mutant proα chains into type I procollagen molecules are functionally “null” and associated with a relatively mild...
Paper Details
Title
Sequence Alterations in the Carboxyl-Terminal Propeptide Domain
Published Date
Jan 1, 2014
Journal
Pages
129 - 140
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