Radiogenomics to characterize regional genetic heterogeneity in glioblastoma
Abstract
Background Glioblastoma (GBM) exhibits profound intratumoral genetic heterogeneity. Each tumor comprises multiple genetically distinct clonal populations with different therapeutic sensitivities. This has implications for targeted therapy and genetically informed paradigms. Contrast-enhanced (CE)-MRI and conventional sampling techniques have failed to resolve this heterogeneity, particularly for nonenhancing tumor populations. This study...
Paper Details
Title
Radiogenomics to characterize regional genetic heterogeneity in glioblastoma
Published Date
Aug 8, 2016
Journal
Volume
19
Issue
1
Pages
128 - 137
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