Alpha-actin-2 mutations in Chinese patients with a non-syndromatic thoracic aortic aneurysm

Aortic aneurysms and/or dissection (AADs) in the aorta are a leading cause of human morbidity and mortality. To date, data on non-syndromic thoracic AADs (TAADs) have been mainly derived from Caucasians, and the genetic basis of TAADs remains to be elucidated. In this study, we assessed gene mutations in a Chinese population with TAADs.A cohort of 68 non-syndromic familial TAAD Chinese patients was screened for the most common TAAD-causing genes...