Evaluating the impact of single nucleotide variants on transcription factor binding
Abstract
Diseases and phenotypes caused by disrupted transcription factor (TF) binding are being identified, but progress is hampered by our limited capacity to predict such functional alterations. Improving predictions may be dependent on expanding the set of bona fide TF binding alterations. Allele-specific binding (ASB) events, where TFs preferentially bind to one of the two alleles at heterozygous sites, reveal the impact of sequence variations in...
Paper Details
Title
Evaluating the impact of single nucleotide variants on transcription factor binding
Published Date
Aug 4, 2016
Journal
Pages
gkw691 - gkw691
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