Original paper
Mitochondrial unfolded protein response controls matrix pre-RNA processing and translation
Abstract
The mitochondrial matrix is unique in that it must integrate the folding and assembly of proteins derived from the nuclear and mitochondrial genomes. In Caenorhabditis elegans, the mitochondrial unfolded protein response (UPRmt) senses matrix protein misfolding and induces a program of nuclear gene expression, including mitochondrial chaperonins, to promote mitochondrial proteostasis. While misfolded mitochondrial-matrix-localized ornithine...
Paper Details
Title
Mitochondrial unfolded protein response controls matrix pre-RNA processing and translation
Published Date
Jun 22, 2016
Journal
Volume
534
Issue
7609
Pages
710 - 713
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Notes
History