Time-Resolved Imaging of Single HIV-1 Uncoating In Vitro and in Living Cells
Abstract
Disassembly of the cone-shaped HIV-1 capsid in target cells is a prerequisite for establishing a life-long infection. This step in HIV-1 entry, referred to as uncoating, is critical yet poorly understood. Here we report a novel strategy to visualize HIV-1 uncoating using a fluorescently tagged oligomeric form of a capsid-binding host protein cyclophilin A (CypA-DsRed), which is specifically packaged into virions through the high-avidity binding...
Paper Details
Title
Time-Resolved Imaging of Single HIV-1 Uncoating In Vitro and in Living Cells
Published Date
Jun 20, 2016
Journal
Volume
12
Issue
6
Pages
e1005709 - e1005709
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