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Correlations Between Personality and Brain Structure: A Crucial Role of Gender

Published on Jul 7, 2016in Cerebral Cortex 5.44
· DOI :10.1093/cercor/bhw191
Alessandra D. Nostro2
Estimated H-index: 2
(HHU: University of Düsseldorf),
Veronika I. Müller15
Estimated H-index: 15
(HHU: University of Düsseldorf)
+ 1 AuthorsSimon B. Eickhoff82
Estimated H-index: 82
(HHU: University of Düsseldorf)
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Abstract
Previous studies have shown that males and females differ in personality and gender differences have also been reported in brain structure. However, effects of gender on this "personality-brain" relationship are yet unknown. We therefore investigated if the neural correlates of personality differ between males and females. Whole brain voxel-based morphometry was used to investigate the influence of gender on associations between NEO FFI personality traits and gray matter volume (GMV) in a matched sample of 182 males and 182 females. In order to assess associations independent of and dependent on gender, personality-GMV relationships were tested across the entire sample and separately for males and females. There were no significant correlations between any personality scale and GMV in the analyses across the entire sample. In contrast, significant associations with GMV were detected for neuroticism, extraversion, and conscientiousness only in males. Interestingly, GMV in left precuneus/parieto-occipital sulcus correlated with all 3 traits. Thus, our results indicate that brain structure-personality relationships are highly dependent on gender, which might be attributable to hormonal interplays or differences in brain organization between males and females. Our results thus provide possible neural substrates of personality-behavior relationships and underline the important role of gender in these associations.
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  • References (105)
  • Citations (18)
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References105
Newest
Published on Dec 1, 2015in Reproductive Biology and Endocrinology 2.59
Zhangshun Liu2
Estimated H-index: 2
(SJTU: Shanghai Jiao Tong University),
Jie Liu2
Estimated H-index: 2
(SJTU: Shanghai Jiao Tong University)
+ 3 AuthorsMinfang Tao2
Estimated H-index: 2
(SJTU: Shanghai Jiao Tong University)
Background Level of the testosterone in a man’s life span is very important. Studies on the serum testosterone concentrations in different age groups of healthy men were controversial. The aim of this study was to investigate dynamic changes of serum reproductive hormones with aging in healthy Chinese male and to compare its correlation with age.
Published on Sep 1, 2015in NeuroImage 5.81
Nina Lisofsky6
Estimated H-index: 6
(MPG: Max Planck Society),
Johan Mårtensson12
Estimated H-index: 12
(MPG: Max Planck Society)
+ 3 AuthorsSimone Kühn40
Estimated H-index: 40
(MPG: Max Planck Society)
Hippocampal volume has been shown to be sensitive to variations in estrogen and progesterone levels across rodents' estrous cycle. However, little is known about the covariation of hormone levels and brain structure in the course of the human menstrual cycle. Here, we examine this covariation with a multi-method approach that includes several brain imaging methods and hormonal assessments. We acquired structural and functional scans from 21 naturally cycling women on four time points during thei...
Published on May 1, 2015in Brain Structure & Function 3.62
Harry R. Smolker5
Estimated H-index: 5
(CU: University of Colorado Boulder),
Brendan E. Depue17
Estimated H-index: 17
(CU: University of Colorado Boulder)
+ 2 AuthorsMarie T. Banich60
Estimated H-index: 60
(CU: University of Colorado Boulder)
Although the relationship between structural differences within the prefrontal cortex (PFC) and executive function (EF) has been widely explored in cognitively impaired populations, little is known about this relationship in healthy young adults. Using optimized voxel-based morphometry (VBM), surface-based morphometry (SBM), and fractional anisotropy (FA) we determined the association between regional PFC grey matter (GM) morphometry and white matter tract diffusivity with performance on tasks t...
Published on Mar 31, 2015in PLOS ONE 2.78
Claire L. Kelly2
Estimated H-index: 2
(Fylde College, Lancaster University),
Sandra I. Sünram-Lea15
Estimated H-index: 15
(Fylde College, Lancaster University),
Trevor J. Crawford32
Estimated H-index: 32
(Fylde College, Lancaster University)
Research shows that self-control is resource limited and there is a gradual weakening in consecutive self-control task performance akin to muscle fatigue. A body of evidence suggests that the resource is glucose and consuming glucose reduces this effect. This study examined the effect of glucose on performance in the antisaccade task - which requires self-control through generating a voluntary eye movement away from a target - following self-control exertion in the Stroop task. The effects of mo...
Published on Mar 19, 2015in Gerontology 3.35
Daniel Zimprich23
Estimated H-index: 23
,
Tanja Kurtz3
Estimated H-index: 3
Typically, subjective memory assessments (be it in form of single items or questionnaires) in old age only weakly correlate with the performance in objective memory tests at cross-section. It thus app
Published on Feb 1, 2015in NeuroImage 5.81
Danilo Bzdok21
Estimated H-index: 21
(HHU: University of Düsseldorf),
Adrian Heeger1
Estimated H-index: 1
(HHU: University of Düsseldorf)
+ 6 AuthorsSimon B. Eickhoff82
Estimated H-index: 82
(HHU: University of Düsseldorf)
Abstract The posterior medial cortex (PMC) is particularly poorly understood. Its neural activity changes have been related to highly disparate mental processes. We therefore investigated PMC properties with a data-driven exploratory approach. First, we subdivided the PMC by whole-brain coactivation profiles. Second, functional connectivity of the ensuing PMC regions was compared by task-constrained meta-analytic coactivation mapping (MACM) and task-unconstrained resting-state correlations (RSFC...
Published on Feb 1, 2015in Neuroscience & Biobehavioral Reviews 8.00
L. A. Barros2
Estimated H-index: 2
(UNIFESP: Federal University of São Paulo),
Sergio Tufik56
Estimated H-index: 56
(UNIFESP: Federal University of São Paulo),
Monica L. Andersen38
Estimated H-index: 38
(UNIFESP: Federal University of São Paulo)
Abstract Memory comprises acquisition, consolidation and retrieval of information. Many substances can influence these different phases. It is well demonstrated that sex hormones, mainly estrogen, impact cognitive function. More recently, progesterone has also been documented as playing an important role in cognition, since it influences brain regions involved in memory. Currently, many women are under hormone treatment, which contain progesterone to decrease the risk of development of endometri...
Published on Jan 30, 2015in Frontiers in Integrative Neuroscience
Sophie Doose-Grünefeld1
Estimated H-index: 1
(HHU: University of Düsseldorf),
Simon B. Eickhoff82
Estimated H-index: 82
(HHU: University of Düsseldorf),
Veronika I. Müller15
Estimated H-index: 15
(HHU: University of Düsseldorf)
Alterations in the processing of emotional stimuli (e.g. facial expressions, prosody, music) have repeatedly been reported in patients with major depression. Such impairments may result from the likewise prevalent executive deficits in these patients. However, studies investigating this relationship are rare. Moreover, most studies to date have only assessed impairments in unimodal emotional processing, whereas in real life, emotions are primarily conveyed through more than just one sensory chan...
Published on Jan 1, 2015in Neuropsychobiology 1.68
Maureen M. J. Smeets-Janssen1
Estimated H-index: 1
,
Karin Roelofs32
Estimated H-index: 32
(Radboud University Nijmegen)
+ 4 AuthorsErik J. Giltay51
Estimated H-index: 51
(LEI: Leiden University)
Background: Testosterone has been postulated as a ‘social' hormone, but the relationship between testosterone and personality traits linked with socially oriented
Published on Jan 1, 2015in Frontiers in Neuroscience 3.65
Carl Wolfgang Schøyen Pintzka4
Estimated H-index: 4
(NTNU: Norwegian University of Science and Technology),
Tor Ivar Hansen7
Estimated H-index: 7
(NTNU: Norwegian University of Science and Technology)
+ 1 AuthorsAsta Håberg29
Estimated H-index: 29
(NTNU: Norwegian University of Science and Technology)
To date, there is no consensus whether sexual dimorphism in the size of neuroanatomical structures exists, or if such differences are caused by choice of intracranial volume (ICV) correction method. When investigating volume differences in neuroanatomical structures, corrections for variation in ICV are used. Commonly applied methods are the ICV-proportions, ICV-residuals and ICV as a covariate of no interest, ANCOVA. However, these different methods give contradictory results with regard to pre...
Cited By18
Newest
Published in Scientific Reports 4.01
Song Wang7
Estimated H-index: 7
(Sichuan University),
Yajun Zhao4
Estimated H-index: 4
(MUC: Minzu University of China)
+ -3 AuthorsQiyong Gong53
Estimated H-index: 53
(Sichuan University)
In the long history of identifying factors to predict academic performance, conscientiousness, a so-called ‘big five’ personality trait describing self-regulation and goal-directed behavior, has emerged as a stable predictor for this purpose. However, the neuroanatomical substrates of trait conscientiousness and the underlying brain mechanism linking trait conscientiousness and academic performance are still largely unknown. Here, we examined these issues in 148 high school students within the s...
Published on Jun 4, 2019in bioRxiv
Reut Avinun6
Estimated H-index: 6
(Duke University),
Salomon Israel27
Estimated H-index: 27
(HUJI: Hebrew University of Jerusalem)
+ -2 AuthorsAhmad R. Hariri71
Estimated H-index: 71
(Duke University)
Attempts to link the Big Five personality traits of Openness, Conscientiousness, Extraversion, Agreeableness, and Neuroticism with variability in trait-like features of brain structure have produced inconsistent results. Small sample sizes and heterogeneous methodology have been suspected in driving these inconsistencies. Here, we tested for associations between the Big Five personality traits and multiple measures of brain structure using data from 1,107 university students (636 women, mean age...
Published on May 24, 2019in bioRxiv
Sofie L. Valk6
Estimated H-index: 6
(HHU: University of Düsseldorf),
Felix Hoffstaedter14
Estimated H-index: 14
(HHU: University of Düsseldorf)
+ 3 AuthorsSimon B. Eickhoff82
Estimated H-index: 82
(HHU: University of Düsseldorf)
Personality traits are influenced by genetic and environmental factors and are related to mental health. Previous neuroimaging studies have reported associations between personality and brain structure, while at the same time, studies on imaging genetics have repeatedly demonstrated heritability of brain structure. However, to date, it is unknown whether the association between personality and brain macrostructure can be explained by shared genetic factors. Here we report a large-scale twin stud...
Published on Apr 24, 2019in Frontiers in Psychology 2.13
Daphne Stem (Katholieke Universiteit Leuven), Yun-An Huang2
Estimated H-index: 2
(Katholieke Universiteit Leuven),
Jan Van den Stock23
Estimated H-index: 23
Published on Apr 3, 2019in Psychophysiology 3.38
Lauren Delaparte4
Estimated H-index: 4
(SBU: Stony Brook University),
Elizabeth Bartlett2
Estimated H-index: 2
(SBU: Stony Brook University)
+ 5 AuthorsRoman Kotov36
Estimated H-index: 36
(SBU: Stony Brook University)
Published on Mar 13, 2019in eLife 7.55
Shahrzad Kharabian Masouleh1
Estimated H-index: 1
(HHU: University of Düsseldorf),
Simon B. Eickhoff82
Estimated H-index: 82
(HHU: University of Düsseldorf)
+ 2 AuthorsAlzheimer's Disease Neuroimaging Initiative
All human brains share the same basic structure. But no two brains are exactly alike. Brain scans can reveal differences between people in the organization and activity of individual brain regions. Studies have suggested that these differences give rise to variation in personality, intelligence and even political preferences. But recent attempts to replicate some of these findings have failed, questioning the existence of such a direct link, specifically between brain structure and human behavio...
Published on Mar 13, 2019in eLife 7.55
Shahrzad Kharabian Masouleh1
Estimated H-index: 1
(HHU: University of Düsseldorf),
Simon B. Eickhoff82
Estimated H-index: 82
(HHU: University of Düsseldorf)
+ 2 AuthorsAlzheimer's Disease Neuroimaging Initiative1
Estimated H-index: 1
All human brains share the same basic structure. But no two brains are exactly alike. Brain scans can reveal differences between people in the organization and activity of individual brain regions. Studies have suggested that these differences give rise to variation in personality, intelligence and even political preferences. But recent attempts to replicate some of these findings have failed, questioning the existence of such a direct link, specifically between brain structure and human behavio...
Published on Dec 1, 2018in NeuroImage 5.81
Rongtao Jiang4
Estimated H-index: 4
(CAS: Chinese Academy of Sciences),
Vince Daniel Calhoun87
Estimated H-index: 87
(UNM: University of New Mexico)
+ 9 AuthorsMing Song16
Estimated H-index: 16
(CAS: Chinese Academy of Sciences)
Abstract Temperament consists of multi-dimensional traits that affect various domains of human life. Evidence has shown functional connectome-based predictive models are powerful predictors of cognitive abilities. Putatively, individuals' innate temperament traits may be predictable by unique patterns of brain functional connectivity (FC) as well. However, quantitative prediction for multiple temperament traits at the individual level has not yet been studied. Therefore, we were motivated to rea...