Small interfering RNA delivery into the liver by cationic cholesterol derivative-based liposomes
Abstract
Purpose: Previously, we reported that the cationic liposomes composed of a cationic cholesterol derivative, cholesteryl (2-((2-hydroxyethyl)amino)ethyl)carbamate (OH-C-Chol) and 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE) (termed LP-C), could deliver small interfering RNAs (siRNAs) with high transfection efficiency into tumor cells. In this study, to develop a liposomal vector for siRNA delivery in vivo, we prepared the...
Paper Details
Title
Small interfering RNA delivery into the liver by cationic cholesterol derivative-based liposomes
Published Date
Jul 21, 2016
Journal
Volume
27
Issue
4
Pages
264 - 273
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