Intracellular and extracellular microRNA: An update on localization and biological role
Volume: 51, Issue: 3-4, Pages: 33 - 49
Published: Nov 1, 2016
Abstract
MicroRNA (miRNA) is a class of small non-coding RNAs which mediate post-transcriptional gene silencing (PTGS) by sequence-specific inhibition of target mRNAs translation and/or lowering their half-lives in the cytoplasm. Together with their binding partners, Argonaute (AGO) proteins, miRNAs form cores of RNA-induced silencing complexes (RISC). Despite a substantial progress in understanding RISC structure, until recently little was known about...
Paper Details
Title
Intracellular and extracellular microRNA: An update on localization and biological role
Published Date
Nov 1, 2016
Volume
51
Issue
3-4
Pages
33 - 49
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