NOS Expression and NO Function in Glioma and Implications for Patient Therapies

Significance: Gliomas are central nervous system tumors that primarily occur in the brain and arise from glial cells. Gliomas include the most common malignant brain tumor in adults known as grade IV astrocytoma, or glioblastoma (GBM). GBM is a deadly disease for which the most significant advances in treatment offer an improvement in survival of only ∼2 months. Critical Issues: To develop novel treatments and improve patient outcomes, we and...