Omega-3 fatty acids and mortality in patients referred for coronary angiography. The Ludwigshafen Risk and Cardiovascular Health Study.

Published on Sep 1, 2016in Atherosclerosis 4.47
· DOI :10.1016/j.atherosclerosis.2016.06.049
Marcus E. Kleber45
Estimated H-index: 45
(Heidelberg University),
Graciela Delgado19
Estimated H-index: 19
(Heidelberg University)
+ 2 AuthorsClemens von Schacky25
Estimated H-index: 25
(Ludwig Maximilian University of Munich)
Abstract
Background Saturated fatty acids are thought to be harmful by increasing the risk for cardiovascular events. Objective We examined the associations of erythrocyte saturated fatty acids with total and cardiovascular mortality in patients referred for coronary angiography. Methods Red blood cell saturated fatty acid (RBC SFA) proportions were measured by gas chromatography at baseline in 3259 participants of the Ludwigshafen Risk and Cardiovascular Health study. Associations of saturated fatty acid concentrations with mortality were investigated using Cox proportional hazards regression. Results During a median follow-up of 9.9 years, 975 patients (29.9%) died and 614 patients (18.8%) died of cardiovascular causes. The proportion of palmitic acid (PA, C16:0) ranged from 15.1% to 27.4% with a mean (standard deviation) of 21.9% (1.15%) and was associated with an increased risk for mortality in models adjusted for conventional cardiovascular risk factors. An increase of 1-standard deviation in PA was associated with a hazard ratio (95% confidence interval) of 1.08 (1.01–1.16) for all cause and 1.05 (0.96–1.15) for cardiovascular mortality after adjustment for cardiovascular risk factors. For the other investigated RBC SFA (C14:0, C18:0, C20:0, C22:0, and C24:0), there was no association with mortality and also not for the sum of all saturated fatty acids. Conclusions Our results reveal association with increased mortality risk only for PA but not for the other RBC SFAs or the sum of all RBC SFAs and emphasize the need to investigate each fatty acid individually rather than studying groups of fatty acids.
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References100
Published on Oct 1, 2015in Journal of the American College of Cardiology 16.83
Yanping Li42
Estimated H-index: 42
(Harvard University),
Adela Hruby18
Estimated H-index: 18
(Harvard University)
+ 8 AuthorsBarry M. Popkin317
Estimated H-index: 317
(Harvard University)
Abstract Background The associations between dietary saturated fats and the risk of coronary heart disease (CHD) remain controversial, but few studies have compared saturated with unsaturated fats and sources of carbohydrates in relation to CHD risk. Objectives This study sought to investigate associations of saturated fats compared with unsaturated fats and different sources of carbohydrates in relation to CHD risk. Methods We followed 84,628 women (Nurses’ Health Study, 1980 to 2010), and 42,9...
132 Citations Source Cite
Published on Feb 1, 2006in The American Journal of Clinical Nutrition 6.55
Irena B. King39
Estimated H-index: 39
(Fred Hutchinson Cancer Research Center),
Rozenn N Lemaitre1
Estimated H-index: 1
(Fred Hutchinson Cancer Research Center),
Mark Kestin13
Estimated H-index: 13
(Fred Hutchinson Cancer Research Center)
Background : The utility of fatty acids (FAs) as biomarkers of total fat intake is unknown. Objective : We compared FA changes in red cells (RCs), plasma phospholipids (PLs), and cholesterol esters (CEs) in response to a low-fat diet (LFD) and a moderate-fat diet (MFD) and assessed whether individual or combination of FAs predict LFD. Design : Postmenopausal women ( n = 66) were randomly assigned to receive an LFD (17% of energy from fat) or an MFD (34% of energy from fat) for 6 wk. All foods we...
94 Citations Source Cite
Published on Jun 1, 2006in The American Journal of Clinical Nutrition 6.55
Sarah K Gebauer9
Estimated H-index: 9
(University of Missouri–Kansas City),
Tricia Psota7
Estimated H-index: 7
(University of Missouri–Kansas City)
+ 1 AuthorsPenny M. Kris-Etherton88
Estimated H-index: 88
(University of Missouri–Kansas City)
Dietary recommendations have been made for n-3 fatty acids, including α-linolenic acid (ALA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA) to achieve nutrient adequacy and to prevent and treat cardiovascular disease. These recommendations are based on a large body of evidence from epidemiologic and controlled clinical studies. The n-3 fatty acid recommendation to achieve nutritional adequacy, defined as the amount necessary to prevent deficiency symptoms, is 0.6-1.2% of energy for...
396 Citations Source Cite
Published on Oct 31, 2015in Annals of Nutrition and Metabolism 3.05
Günther Wolfram23
Estimated H-index: 23
,
Angela Bechthold10
Estimated H-index: 10
+ 9 AuthorsJessica Dinter1
Estimated H-index: 1
As nutrition-related chronic diseases have become more and more frequent, the importance of dietary prevention has also increased. Dietary fat plays a major role in human nutrition, and modification o
24 Citations Source Cite
Published on Jul 28, 2015in Circulation 18.88
Vasanti S. Malik34
Estimated H-index: 34
(Harvard University),
Stephanie E. Chiuve43
Estimated H-index: 43
(Harvard University)
+ 4 AuthorsQi Sun62
Estimated H-index: 62
(Harvard University)
Background—Circulating very-long-chain saturated fatty acids (VLCSFAs) may play an active role in the origin of cardiometabolic diseases. Methods and Results—We measured 3 VLCSFAs (C20:0, C22:0, and C24:0) in plasma and erythrocytes using gas-liquid chromatography among 794 incident coronary heart disease (CHD) cases who were prospectively identified and confirmed among women in the Nurses’ Health Study (NHS; 1990–2006) and among men in the Health Professionals Follow-Up Study (HPFS; 1994–2008)....
17 Citations Source Cite
Published on Oct 1, 2012in Lipids 1.94
Penny M. Kris-Etherton88
Estimated H-index: 88
(Pennsylvania State University),
Michael Lefevre34
Estimated H-index: 34
(Utah State University)
+ 3 AuthorsBrent Flickinger9
Estimated H-index: 9
Because of efforts to decrease trans fatty acids (TFA) in the food supply, intake should be assessed in the population to establish a baseline TFA intake. The 1999–2002 National Health and Nutrition Examination Survey (NHANES) was used to identify a benchmark for TFA intake. TFA was estimated by mean, median, and quintile of intake, TFA intake data were weighted using the NHANES 4-year sample weights. The main outcome measures included TFA intake in grams per day and percentage of energy in the ...
51 Citations Source Cite
Published on Dec 1, 2004in Lipids 1.94
A.L. Lock29
Estimated H-index: 29
(Cornell University),
Dale E. Bauman79
Estimated H-index: 79
(Cornell University)
There is increased consumer awareness that foods contain microcomponents that may have beneficial effects on health maintenance and disease prevention. In milk fat these functional food components include EPA, DHA, and CLA. The opportunity to enhance the content of these FA in milk has improved as a result of recent advances that have better defined the interrelationships between rumen fermentation, lipid metabolism, and milk fat synthesis. Dietary lipids undergo extensive hydrolysis and biohydr...
396 Citations Source Cite
Published on May 1, 2006in Atherosclerosis Supplements 3.08
Margaret C. Craig-Schmidt10
Estimated H-index: 10
(Auburn University)
Abstract Dietary trans fatty acids (TFA) originate from commercially hydrogenated oils and from dairy and meat fats. Estimates of dietary TFA consumption vary with dietary habits and food supply as well as methods used to estimate consumption. Methods include: (1) market share data, (2) laboratory analysis of duplicate portions or composite diets, (3) analysis of consumption data of a representative population, and (4) biomarkers, such as human milk. In North America, daily intakes have been est...
119 Citations Source Cite
Published on Jun 1, 2002in Lipids 1.94
Robert L. Wolff7
Estimated H-index: 7
(Institut national de la recherche agronomique),
Dietz Precht13
Estimated H-index: 13
21 Citations Source Cite
Published on Dec 21, 2010in Annals of Internal Medicine 19.38
Dariush Mozaffarian111
Estimated H-index: 111
,
Haiming Cao12
Estimated H-index: 12
+ 4 AuthorsGökhan S. Hotamisligil98
Estimated H-index: 98
Background: Palmitoleic acid (cis-16:1n-7), which is produced by endogenous fat synthesis, has been linked to both beneficial and deleterious metabolic effects, potentially confounded by diverse determinants and tissue sources of endogenous production. Trans-palmitoleate (trans-16:1n-7) represents a distinctly exogenous source of 16:1n-7, unconfounded by endogenous synthesis or its determinants, that may be uniquely informative. Objective: To investigate whether circulating trans-palmitoleate is...
194 Citations Source Cite
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Published on Sep 1, 2016in Data in Brief
Marcus E. Kleber45
Estimated H-index: 45
(Heidelberg University),
Graciela Delgado19
Estimated H-index: 19
(Heidelberg University)
+ 2 AuthorsClemens von Schacky25
Estimated H-index: 25
(Ludwig Maximilian University of Munich)
This paper contains additional data related to the research article “Omega-3 fatty acids and mortality in patients referred for coronary angiography – The Ludwigshafen Risk and Cardiovascular Health Study” (Kleber et al., in press) [1]. The data shows characteristics of the Ludwigshafen Risk and Cardiovascular Health (LURIC) study according to tertiles of omega-3 fatty acids as well as stratified by gender. The association of proportions of omega-3 fatty acids measured in erythrocyte membranes w...
3 Citations Source Cite
Published on Sep 1, 2016in Atherosclerosis 4.47
William S. Harris73
Estimated H-index: 73
(University of South Dakota)
1 Citations Source Cite
Published on Jan 1, 2017in Journal of Clinical Lipidology 3.58
William S. Harris73
Estimated H-index: 73
(University of South Dakota),
Juhua Luo18
Estimated H-index: 18
(Indiana University Bloomington)
+ 6 AuthorsJennifer G. Robinson56
Estimated H-index: 56
(University of Iowa)
Background The prognostic value of circulating polyunsaturated fatty acid (PUFA) levels is unclear. Objectives To determine the associations between red blood cell (RBC) PUFA levels and risk for death. Methods This prospective cohort study included 6501 women aged 65 to 80 years who participated in the Women's Health Initiative Memory Study (enrolment began 1996). RBC PUFA levels were measured at baseline and expressed as a percent of total RBC PUFAs. PUFAs of primary interest were the n-3 PUFAs...
14 Citations Source Cite
Published on Mar 1, 2017in Lipids 1.94
Elena Dreassi19
Estimated H-index: 19
(University of Siena),
Annarita Cito2
Estimated H-index: 2
(Consiglio per la ricerca e la sperimentazione in agricoltura)
+ 3 AuthorsValeria Francardi9
Estimated H-index: 9
(Consiglio per la ricerca e la sperimentazione in agricoltura)
Fat is the second most abundant component of the nutrient composition of the mealworm Tenebrio molitor (Coleoptera: Tenebrionidae) that represents also an interesting source of PUFA, especially n-6 and n-3 fatty acids, involved in prevention of cardiovascular diseases. This study investigated the possibility of modifying the fat content and the FA composition of yellow mealworms through feeding and how this would be influenced by developmental stages, pupal sex, and generation with the future ai...
9 Citations Source Cite
Published on Jul 1, 2017in Atherosclerosis 4.47
William S. Harris73
Estimated H-index: 73
(University of South Dakota),
Liana C. Del Gobbo20
Estimated H-index: 20
(Stanford University),
Nathan L. Tintle19
Estimated H-index: 19
(Dordt College)
Abstract Background and aims A recent 19-cohort meta-analysis examined the relationships between biomarkers of omega-3 fatty acids and risk for coronary heart disease (CHD). That study did not, however, report hazard ratios (HRs) specifically as a function of erythrocyte eicosapentaenoic (EPA) plus docosahexaenoic (DHA) levels, a metric called the Omega-3 Index in which EPA + DHA content is expressed as a percent of total fatty acids. The Omega-3 Index has been used in several recent studies and...
23 Citations Source Cite
Published on Jul 1, 2017in Journal of Clinical Lipidology 3.58
Graciela Delgado19
Estimated H-index: 19
(Heidelberg University),
Winfried März85
Estimated H-index: 85
(University of Graz)
+ 2 AuthorsMarcus E. Kleber45
Estimated H-index: 45
(University of Jena)
Background Omega-6 polyunsaturated fatty acids (omega-6 PUFA) are recommended in European cardiovascular prevention guidelines. However, individual fatty acids have distinct biological functions, and there have been conflicting reports about the association of omega-6 PUFA with cardiovascular risk. Objective The aim of our study was to investigate the association of individual omega-6 fatty acids with mortality in a cohort of patients referred for coronary angiography. Methods Omega-6 PUFA propo...
7 Citations Source Cite
Barbara A. Fielding49
Estimated H-index: 49
Purpose of review In 2004, the ‘omega-3 index’ was described as the sum of eicosapentaenoic acid (EPA, 20:5 n-3) and docosahexaenoic acid (DHA, 22:6 n-3) in red blood cells (RBCs) as an index of coronary heart disease mortality. This review outlines new evidence to support the omega-3 index as a tool to inform disease prognosis. Recent findings Recent studies have reported differential metabolism of EPA and DHA. High dose supplementation with EPA and DHA led to increased levels of RBC DHA that w...
2 Citations Source Cite
Published on Jun 19, 2017in Nutrients 4.20
Anton Köhler3
Estimated H-index: 3
,
Johanna Heinrich1
Estimated H-index: 1
,
Clemens von Schacky25
Estimated H-index: 25
A low Omega-3 Index (eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) in erythrocytes) is associated with cardiac, cerebral, and other health issues. Intake of EPA and DHA, but not of alpha-linolenic acid (ALA), increases the Omega-3 Index. We investigated bioavailability, safety, palatability and tolerability of EPA and DHA in a novel source: a variety of sausages. We screened 96 healthy volunteers, and recruited 44 with an Omega-3 Index <5%. Participants were randomly assigned to rec...
1 Citations Source Cite
Published on Oct 1, 2017in Biochimica et Biophysica Acta 3.44
Natalie Fournier16
Estimated H-index: 16
,
Guillaume Sayet1
Estimated H-index: 1
+ 7 AuthorsJean-Louis Paul23
Estimated H-index: 23
Abstract A diet containing a high n − 3/n − 6 polyunsaturated fatty acids (PUFA) ratio has cardioprotective properties. PUFAs incorporation into membranes influences the function of membrane proteins. We investigated the impact of the membrane incorporation of PUFAs, especially eicosapentaenoic acid (EPA) (C20:5 n − 3), on the anti-atherogenic cholesterol efflux pathways. We used cholesteryl esters (CE)-loaded human monocyte-derived macrophages (HMDM) to mimic foam cells exposed to the FAs for a...
2 Citations Source Cite
Published on Oct 1, 2017in Deutsche Medizinische Wochenschrift 0.52
Katharina Lechner , Nicole Erickson4
Estimated H-index: 4
+ 1 AuthorsFlorian Horn
Cardiovascular disease is the number one cause of death globally. Poor diet constitutes a key factor in the initiation and progression of cardiovascular disease and has become the leading risk factor for disability and death worldwide. Therefore, addressing suboptimal nutrition is of key prognostic relevance in primary and secondary prevention of metabolic vascular syndrome. Metabolic vascular syndrome is a multidimensional network of acquired cardiometabolic risk factors closely related to insu...
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