Metabolic responses to dietary protein restriction require an increase in FGF21 that is delayed by the absence of GCN2

Volume: 16, Issue: 3, Pages: 707 - 716
Published: Jul 19, 2016
Abstract
Summary null FGF21 contributes to the metabolic response to dietary protein restriction, and prior data implicate GCN2 as the amino acid sensor linking protein restriction to FGF21 induction. Here, we demonstrate the persistent and essential role of FGF21 in the metabolic response to protein restriction. We show that null Fgf21 null KO mice are fully resistant to low protein (LP)-induced changes in food intake, energy expenditure (EE), body...
Paper Details
Title
Metabolic responses to dietary protein restriction require an increase in FGF21 that is delayed by the absence of GCN2
Published Date
Jul 19, 2016
Volume
16
Issue
3
Pages
707 - 716
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